Abstract
The purpose of the present study is to clarify the disease of disseminated intravascular coagulation (DIC).We designed an experimental model of DIC in rabbits induced by continuous infusion of endotoxin (ET) for three hours. The animals were divide into four groups as follows;Group I: infusion with ET (0.1mg/kg)+physiological salineGroup II: infusion with ET (1.0mg/kg)+physiological salineGroup III: infusion with ET (3.0mg/kg)+physiological salineGroup IV: infusion with physiological saline only (control).Tentative diagnostic criteria for experimental DIC were proposed as DIC score including various blood parameters and pathological findings (micro-clot formation in lung and kidney). The results indicated that aggravations of blood parameters and pathological findings were dependent upon the dose of ET, and Group III made the highest score in on studies.From these results, we may conclude that Group III was considered to be useful as DIC model in rabbits.
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