Abstract
Angiogenesis is a genetically determined mechanism for the formation of new vessels from progenitor cells; it is also a complex process of new vessels formation, that is regulated by an imbalance in the pro- and anti-angiogenic factors ratio. Angiogenesis is divided on physiological and pathological, which directly refers to angiogenesis in conditions of tumor pathology, and in conditions of inflammatory diseases. So the fundamental differences in the mechanisms base in the direct synthesis of vascular growth factors in tumor cells, or the release of pro-angiogenic factors by immune and stromal cells. Under conditions of inflammation, cytokines can directly induce vascular synthesis by recruiting angioblasts, or, indirectly, by inducing leukocytes and endothelial cells for the synthesis of pro-angiogenic mediators.
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