Запор и мультиморбидная патология: взгляд педиатра

Abstract

The prevalence of constipation among the Russian child population is extremely high. Chronic constipation is a classic example of a multimorbidity and has significant, including disabling, consequences for the child's health. The syndrome of increased intestinal permeability, which occurs with chronic constipation, forms a whole block of systemic pathology involving almost all human systems and organs. More than half (51.7%) of children with chronic constipation have symptoms of chronic fecal intoxication. The article highlights the etiopathogenetic aspects of the increased intestinal permeability in patients with chronic constipation. The article also discusses the association of intestinal motility disorders with the development of dermatosis, urinary tract pathology, allergic, mental and other diseases. The butyrate role as a key molecule of intestinal metabolism is considered. The importance of lactitol in the constipation treatment and increased intestinal permeability correction is also shown. This drug has a complex effect: during its use, there is an increase in the bowel movement frequency, a decrease in the constipation symptoms, as well as the regulation of the intestinal barrier to protect the body from the constipation effects. KEYWORDS: increased intestinal permeability, constipation, multimorbidity, short-chain fatty acids, butyrate, laxative, lactitol. FOR CITATION: Nizhevich A.A., Valeeva D.S., Loginovskaya V.V. Constipation and multimorbidity: a pediatrician's view. Russian Journal of Woman and Child Health. 2024;7(1):71–78 (in Russ.). DOI: 10.32364/2618-8430-2024-7-1-11.