Abstract
Lobenzarit-2Na (CCA) is a new antirheumatoid arthritis agent and is reported to show an immuno-modulatory effects clinically and pre-clinically. Immunological modification by CCA in vivo and in vitro is so complicated, and it is difficult to expect CCA to exert its effect by activating or inhibiting a specific enzyme (s) . Actually it was reported that CCA had no inhibitory effect on cyclooxygenase.Previously it was shown that RNA polymerase activity in nuclear suspension isolated from lymphonode was activated in a double-peaked fashion by CCA. A detailed study on RNA polymerase-I activity in nuclear suspension isolated from rat liver indicated an indirect effect of CCA on RNA polymerase-I, as described in this report. We deduce here that CCA affects the reactivity of cytoskeleton, which attaches periphery of nucleus, and that the organization state of cytoskeleton in nuclear suspension is responsible for the regulation of nucleolar enzyme, RNA polymerase-I activity.This and following reports give a strong suggestion that CCA can modify the reactivity of cytoskeleton, resulting in a non-unidirectional modification of cellular function, or immuno-modulation.
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