저체온사 진단을 위한 사후 진단마커 연구

Abstract

Since the diagnosis of death due to hypothermia is pathologically non-specific and the macroscopic findings are sometimes uncertain, a biochemical diagnostic analysis method for the precision of the diagnosis of hypothermia is required. Although general hypothermic death was diagnosed as an increase in ketone body concentration, as a result of statistical analysis of the correlation between hypothermic death and ketone body concentration assessed by the National Forensic Service in recent years, the ketone body concentration of hypothermic death in the case of not drinking or drinking a little is higher than the general death rate, in the case of death due to hypothermia after drinking a large amount of alcohol, the ketone body concentration showed a tendency to be inversely proportional to the blood alcohol concentration. Therefore, there is a need for a new biochemical diagnostic marker that can replace the ketone body concentration analysis in the diagnosis of death due to hypothermia. In this study, about 30 cases of hypothermic death and 76 cases of general death control were selected. Concentration changes of biochemical diagnostic indicators such as glucose, acetone, β-hydroxybutyrate, free fatty acids, and electrolyte ions were analyzed using ion chromatography (IC) and gas chromatography-mass spectrometry (GC-MS). As a result, it showed the specificity of increasing or decreasing the concentration of electrolytes ion and free fatty acids as biochemical diagnostic markers according to changes in the body at the time of death due to hypothermia.