Abstract
The article is devoted to the scientific substantiation of the optimal composition and technology of rometine suppositories with antiviral, and anti-influenza activity. For many years, studies have been conducted on the introduction of gossypol derivatives into medical practice, since pharmacological studies have shown their high interferon-inducing ability. Rometine is one of the representatives of this group. Given its physicochemical and technological properties, formulations were selected to obtain a rectal dosage form. According to pharmacological studies, a therapeutic dose of - 0.05 g rometine was chosen. The technological stages of obtaining suppositories have been accumulated and qualitative indicators have been studied according to the State Pharmacopoeia, which revealed compliance with the requirements presented in the general article of the “Suppository” GF XI. Experimental methods according to the ND have proved the acceptability of using a hydrophobic basis as carriers. The parameters for the production of anti-influenza suppositories on an industrial scale were studied. For the reliability of the results obtained, it was decided to study the quality of the proposed suppository formulations periodically during the storage. Further, a quantitative determination method was developed by the UV spectrophotometric method, the average result of which revealed the degree of determination of the amount of active substance in the range of 85-105%.
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