Abstract
Objective. To determine the risk of development of placental-related disorders of pregnancy in the presence of single-nucleotide polymorphism rs4065 of the urokinase gene in a mother. Patients and methods. The presence of the genetic variant of the rs4065 urokinase gene was determined in venous blood samples using real-time polymerase chain reaction in patients with placental-related pregnancy disorders and in the control group. Results. Associations between the risk of development of placental-related disorders of pregnancy, such as fetal growth resrtiction and pre-eclampsia, and the maternal rs4065 genotype were found. A correlation between the maternal rs4065 genotype and the degree of fetal growth restriction and the severity of pre-eclampsia was identified. The most unfavorable is the presence of the CC genotype. Conclusion. The presence of single-nucleotide substitutions in the maternal urokinase gene is associated with the development of placental-related disorders of pregnancy. Key words: urokinase-type plasminogen activator, angiogenesis, fetal growth restriction, placental insufficiency, pre-eclampsia, SNP
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