Abstract
The purpose of the present study was to investigate effects of swimming exercise on serum Prostaglandin, E₂ COX-1 and COX-2 mRNA expression in Rheumatoid Arthritis mice’s synovium. DBA/1J mice were injected with collagen into the tail for induction of CIA model. Experimental groups were divided into 3 groups: normal group(n=8), CIA(collagen-induced arthritis) group(n=8), and CIA+SE (collagen-induced arthritis+swimming exercise) group(n=8). After 8 consecutive weeks of swimming exercise, serum prostaglandin E2, IL-1β, IL-6 levels and synovium COX-1 mRNA, COX-1 mRNA were determined. Serum prostaglandin E2, IL-1β, IL-6 levels were significantly reduced in CIA+SE group compared to the CIA group. COX-2 mRNA expression in synovium was significantly reduced in CIA+SE group compared to the CIA group. These observations indicate that the protective effect of swimming exercise against rheumatoid arthritis is mediated via the modulation of inflammatory responses in mice.
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