Abstract
Investigations of the effects of phitochemical compounds from extracts of pomegranate, grape seeds and garlic on expression of NFE2L2, JUN, SOD1 in cultivated cells of the human blood showed that transcription of SOD1 increased in the presence of pomegranate and grape seed extracts. Level of mRNA in NFE2L2 and JUN rose briskly only under the influence of a high concentration of the grape seed extract. Level of JUN mRNA correlated with NFE2L2 mRNA. Garlic extract had no effect on transcription of NFE2L2, JUN, SOD1. Activation of the transcription of all 3 genes under study by the grape seeds extract can contribute to controlling the free radical processes in human cells.
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