Abstract
Неинвазивные методы определения барьерной функции кожи in vivo – преимущества конфокальной микроспектроскопии комбинационного рассеяния света
Highlights
One of the main functions of the skin is the barrier function, i.e. protection against external physical and chemical influences, as well as against the penetration of pathogens into the body
The physical barrier of the stratum corneum (SC) is provided by corneocytes and the lateral organization of intercellular lipids (ICL) [2], which necessarily include the orthorhombic organization phase, a strictly ordered and most densely packed structure [3]
Methods for determining the lateral organization of ICL, which determines the skin barrier function [6], include wide angle and small-angle X-ray scattering, electron diffraction, electron paramagnetic resonance spectroscopy, infrared spectroscopy and confocal Raman microspectroscopy (CRM). All these methods are suitable for measuring skin biopsies ex vivo, and only CRM has an advantage of measuring the lateral organization of ICL in vivo [7, 8]
Summary
One of the main functions of the skin is the barrier function, i.e. protection against external physical and chemical influences, as well as against the penetration of pathogens into the body. The physical barrier of the SC is provided by corneocytes and the lateral organization of intercellular lipids (ICL) [2], which necessarily include the orthorhombic organization phase, a strictly ordered and most densely packed structure [3]. Methods for determining the lateral organization of ICL, which determines the skin barrier function [6], include wide angle and small-angle X-ray scattering, electron diffraction, electron paramagnetic resonance spectroscopy, infrared spectroscopy and confocal Raman microspectroscopy (CRM). All these methods are suitable for measuring skin biopsies ex vivo, and only CRM has an advantage of measuring the lateral organization of ICL in vivo [7, 8]
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