Abstract

 
 
 Vascular endothelial growth factor A (VEGF-A) promotes the survival of endothelial cells during acute myocardial infarction, accelerates the development of collateral blood supply to ischemic myocardium, and affects the size diminishing of the necrotic lesion area. The synthesis of the VEGF- A in response to standard stimuli is different between people that is genetically determined. The aim was to study the association of polymorphous variants of the VEGF-A gene (G634C) with the dynamics of structural and functional parameters of left ventricle in patients with acute ST elevation myocardial infarction (STEMI) during a 6-month period.A significantly higher VEGF-A concentration was determined in the carriers of the GG genotype compared to the GC genotype (p = 0.047) in the acute period. It has been established that the genotype GC in patients with acute myocardial infarction ST-elevation (STEMI) is associated with more pronounced changes in the left ventricular geometry during the acute period. The GC genotype is associated with a better blood pressure control and a decrease in the left ventricle mass after 6 months’ observation.
 
 
Highlights
affects the size diminishing of the necrotic lesion area
The synthesis of the VEGFA in response to standard stimuli is different between people
The aim was to study the association of polymorphous variants of the Vascular endothelial growth factor A (VEGF-A) gene
Summary
Vascular endothelial growth factor A (VEGF-A) promotes the survival of endothelial cells during acute myocardial infarction, accelerates the development of collateral blood supply to ischemic myocardium, and affects the size diminishing of the necrotic lesion area. Кров для визначення ВЕФР-А в сироватці забирали на 5-7 день ГІМпST та через 6 місяців від події. Клінічна характеристика пацієнтів обох груп залежно від генотипів поліморфних варіантів G634C гена ВЕФР-A (rs 2010963)
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