ИЗУЧЕНИЕ РАЗНЫХ ДОЗ ВАКЦИНЫ ИЗ ШТАММА B. ABORTUS 82 ДЛЯ ВАКЦИНАЦИИ СЕВЕРНЫХ ОЛЕНЕЙ

Abstract

According to the official data of the FSBU “ Center Of Veterinary Medicine”, brucellosis is still registered in reindeer herds of the Asian North of the Russian Federation as a whole in Russia in 2019. 48 sites of brucellosis-affected reindeer herds were registered, including 35 in the Sakha Yakutia Republic, 7 in the Yamalo-Nenets Autonomous Region, one in the Taimyr Municipal District and 1 in the Chukchi Autonomous Region. It has been established that without the use of specific prevention measures anti-brucellisis measures in reindeer husbanding farms are not effective. Currently, a vaccine from the low-agglutinogenic strain “B.abortus 82 “is used to immunize reindeer. The purpose of our work is to clarify the optimal dose of the vaccine from the “B.abortus 82”strain based on experimental data on survival, reactogenity, agglutinogenity and duration of intense immunity,when administering different doses of immunopreparate. Based on two controlled experiments, it was established that the optimal dose of the vaccine from the strain “B.abortus 82” can be considered 10 billion m. In this dose, the deer do not have post-vaccination complications, the vaccine strain is well settled in the body of the vac cinated animal and eliminates 30-45 days after administration. The titer agglutinins and complementarity of binding antibodies reaches its maximum by 28 days after immunization and is gradually reduced; 180 days after vaccination agglutinins are registered in minimum credits. Tension of immunity in vaccinated animals was tested by direct infection with the virulent strain, the largest number of immune deer were recorded in 3 and 6 months. after vaccination (65,4 -86.7 % depending on the age group). Only regional infection was reported in infected deer, and the infection index did not exceed 12.8-15.4%.