Пищевое поведение пациентов с сахарным диабетом 2 типа и полиморфизм гена рецептора меланокортина

Abstract

Aim: to analyze the associations of rs17782313 polymorphism of melanocortin type 4 receptor (MC4R) gene in patients with type 2 diabetes (T2D) in Tatar ethnic group (Republic of Bashkortostan) and to determine the types of eating disorders in T2D patients and their association with MC4R allelic variants (rs17782313).Patients and Methods: MC4R rs17782313 gene polymorphism was genotyped by polymerase chain reaction (PCR) in 190 healthy individuals (39 men and 151 women, mean age 55.3±9.8 years) and 200 patients with T2D (57 men and 143 women, mean age 59.2±9.5 years). Eating behavior was assessed using the Dutch Eating Behaviour Questionnaire (DEBQ) in 134 controls and 83 patients with T2D. All individuals belonged to the Tatar ethnic group and lived in the Republic of Bashkortostan. Statistical analysis was performed using Statistica 6.0 and SNPStats software (https://www.snpstats.net/start.htm). Odds ratio (OR) was calculated using online platform (https://www.medcalc.org/calc/odds_ratio.php).Results: higher prevalence of C/C genotype of MC4R rs17782313 gene polymorphism was revealed in T2D patients compared to the controls (6.0% vs. 2.1%, respectively, p=0.0444). T2D patients were characterized by higher “Emotional eating” scores (р<0.00001) but lower “Restrictive eating” scores (р=0.0001) and “External eating” scores (р<0.0047) compared to healthy individuals. MC4R allelic variants (rs17782313) did not demonstrate any associations with eating behavior types in either T2D patients or controls. Conclusion: C/C genotype of rs17782313 MC4R gene polymorphism is a marker of higher risk of T2D in Tatar ethnic group (OR=2.9, p=0,0444). The mechanisms by which MC4R allelic variants (rs17782313) affect T2D pathogenesis require further studies.KEYWORDS: type 2 diabetes, eating behavior, Dutch Eating Behavior Questionnaire, DEBQ, melanocortin receptor type 4 gene, emotional eating, external eating, restrictive eating, genetic susceptibility, Tatar ethnic group.FOR CITATION: Avzaletdinova D.Sh., Morugova T.V., Sharipova L.F., Kochetova O.V. Eating behavior in patients with type 2 diabetes and melanocortin receptor gene polymorphism. Russian Medical Inquiry. 2020;4(6):318–323. DOI: 10.32364/2587-6821-2020-4-6-318-323.