Abstract
Sinonasal mucosal melanoma (SMM) is rare form of melanoma and accounts for 4%-13% of all sinonasal malignant tumor. SMM is characterized by aggressive growth with high locoregional recurrence and distant metastasis. Immunotherapy has been known as effective therapeutic strategies in metastatic melanoma. Immune checkpoint inhibitors; anticytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and antigrogrammed cell death 1 (PD-1), demonstrated the improved prognosis in advanced malignant melanoma. Recently, authors experienced a case of SMM patient with locoregional and distance metastasis, who was successfully treated with anti-PD-1 monoclonal antibody. We report a case of metastatic malignant melanoma with literature review. (J Clinical Otolaryngol 2021;32:265-269)
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