Abstract
Background. The article has explored the problem of the humoral immunity recovery of elderly patients with chronic generalized periodontitis. Such immunological indicators as the immunoglobulin concentrations were used as detectors of inflammatory-destructive disease. Polyoxidonium has been suggested as an immunomodulator, as it promotes faster immune and clinical recovery compared to the conventional treatment regimens. Goals To assess the dynamics of clinical indicators and indicators of humoral immunity (sIgA, IgA, IgG and IgM levels), depending on immunomodulation, is added to the combined treatment regimen of elderly patients with periodontitis. Methods. Two patient cohorts of 69 elderly persons with chronic generalized periodontitis were examined. The conventional treatment was administered in both patient groups. The patients in the second cohort, along with other medications, received Polyoxidonium. The examination included gingival fluid and venous blood sampling, estimation of sIgA, IgA, IgG and IgM concentration as well as evaluation of PMA and SBI indices reduction. Results. The study has revealed the rise of IgG and IgM in venous blood. The recovery trend was observed in both cohorts, with a more marked dynamics in the second one. The mean values of antibodies concentration in the 2-nd group (since the 14th day) were statistically significant compared to the similar measures in the 1st one. After 3 months follow-up the substantial growth of immunoglobulins concentration was registered in the 1st cohort, whereas the 2nd one still showed the recovery trend. Results. The study has revealed the rise of IgG and IgM in venous blood. The recovery trend was observed in both cohorts, with a more marked dynamics in the second one. The mean values of antibodies concentration in the 2-nd group (since the 14th day) were statistically significant compared to the similar measures in the 1st one. After 3 months follow-up the substantial growth of immunoglobulins concentration was registered in the 1st cohort, whereas the 2nd one still showed the recovery trend. Conclusions. The inclusion of immunomodulator Polyoxidonium into the conventional treatment protocol of periodontitis promotes the immunologic reactivity recovery of elderly patients and the improvement of the therapeutic intervention effectiveness over the longer term.
Highlights
The article has explored the problem of the humoral immunity recovery of elderly patients with chronic generalized periodontitis
Но вместе с тем именно они детерминируют актуальность описанной проблемы, что, как это ни парадоксально, роднит гериатрию с педиатрией [6, 9, 15, 16]
Следовательно, в схему комплексного лечения должны быть включены этапы, гармонизирующие иммунные процессы и нормализующие показатели клеточного и гуморального иммунитета [7, 8, 11, 22, 24]
Summary
The article has explored the problem of the humoral immunity recovery of elderly patients with chronic generalized periodontitis. Цель исследования ― оценить динамику клинических показателей, а также факторов гуморального иммунитета (концентрации sIgA, IgA, IgG, IgM) в зависимости от включения этапа иммуномодуляции в схему комплексного лечения лиц пожилого возраста, страдающих хроническим генерализованным пародонтитом. В ДЖ определялась концентрация sIgA (г/л), в крови ― IgA (г/л), IgG (г/л) и IgM (г/л) [8].
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