Abstract
Objective: Psoriasis is a chronic inflammatory skin disease with a complex etiopathogenesis including genetic predisposition, immune dysfunction and environmental factors. Chronic inflammation leads to the development of vascular and metabolic disorders. The bioimpedance method is an easy and useful method for evaluating of body composition. In this study, it was aimed to investigate body composition, demographic, clinical and laboratory data in patients with psoriasis and to compare them with healthy controls. Material and Methods: Sociodemographic characteristics of the participants, duration of disease, concomitant systemic diseases, family history of psoriasis, presence of psoriatic arthritis and current treatments were questioned. Body composition of the participants was determined by Tanita Body Composition Analyzer type BC-418 (Tokyo, Japan), and in blood samples glucose, total cholesterol, HDL, LDL, triglyceride and insulin levels were determined by autoanalysers. Results: HOMA-IR, triglyceride, BMI, metabolic age and fat percentage were significantly higher in the psoriasis group, whereas the control group had higher body density, lean mass, mineral percentage and total body fluid. In this study, it was found that as the insulin resistance, BMI and fat ratio increased, the severity of the disease increased in patients with psoriasis. Also BMI increased in patients with longer disease duration. Topical and conventional therapies had no significant effect on laboratory and body composition parameters. Conclusion: In the light of the data obtained in this study, it was concluded that some metabolic markers and body composition parameters were negatively affected in patients with psoriasis and were associated with disease severity.
Highlights
Psoriasis is a chronic inflammatory disease characterized by erythematous squamous papules and plaques
It has been stated that this condition can be explained by chronic systemic inflammation and secreted proinflammatory cytokines. Many comorbidities such as obesity, atherogenesis, hypertension, cardiovascular disease, Type 2 Diabetes Mellitus have been reported to be more frequent in psoriasis patients [2]
There was a positive correlation between PASI and HOMA-IR, body mass index (BMI) and fat percentage (p and r values were respectively 0.000,0.435; 0.000, 0.556; 0.000, 0.537)
Summary
Psoriasis is a chronic inflammatory disease characterized by erythematous squamous papules and plaques. Immune mechanisms play a role in its pathogenesis. Physical trauma, stress, infections and various drugs are thought to be effective in the etiology [1]. The incidence of insulin resistance and metabolic syndrome has been shown to increase in patients with psoriasis. It has been stated that this condition can be explained by chronic systemic inflammation and secreted proinflammatory cytokines. Many comorbidities such as obesity, atherogenesis, hypertension, cardiovascular disease, Type 2 Diabetes Mellitus have been reported to be more frequent in psoriasis patients [2]
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