Симпатическая иннервация сердца в раннем постнатальном онтогенезе

Abstract

The sympathetic innervation of the heart in rats and kittens of different ages (newborns, 10, 20 and 30 days old) was studied using the retrograde axon transport of Fast Blue (FB) and immunohistochemical method. From the moment of birth, labeled neurons have been detected in the stellate ganglion (SG). In the rat pups and kittens, all FB labeled neurons contained the enzyme of catecholamine synthesis - tyrosine hydroxylase. In kittens, the percentage of labeled neuropeptide Y (NPY) - immunoreactive (IR) neurons during age development increases in the first 20 days of life from 34 to 58%, and calbindin (CB) -IR decreases from birth to 30 days from 45 to 4%. Labeled somatostatin (SOM) -IR neurons were absent in kittens. In rats, SOM-IR neurons (23%) were detected only in newborns and were not detected in the other age groups. In ontogenesis in rats, labeled NPY-IR and CB-IR neurons participating in the innervation of the heart are also detected from the moment of birth (64 and 49%, respectively), but their percentage does not change significantly throughout all the studied age periods. Thus, in the early postnatal ontogenesis, the neurochemical composition of the neurons innervating the heart changes. There are differences in the age-related changes in the neurochemical composition of sympathetic neurons innervating the heart in rats and cats.