Abstract
The pharmacological effect of lecithinized superoxide dismutase(PC-SOD) was evaluated using rat acute renal failure(ARF) model induced by ischemia-reperfusion. When PC-SOD was injected intravenously to rats 1 hr prior to ischemia, the increased plasma creatinine and BUN levels at 24 hr after reperfusion were significantly reduced. Treatment of PC-SOD immediately after reperfusion also reduced both of the increased ones. In while, inactivated PC-SOD(apo PC-SOD) did not show such effects at all. Unmodified SOD(U SOD) decreased the elevated plasma creatinine and BUN levels, but there was no significant difference. Renal SOD activity in ischemic ARF rats was significantly decreased, while renal myeloperoxidase(MPO) activity, a parameter of local infiltration of neutrophils was increased. The distribution study in ischemic ARF rats revealed that [3H] PC-SOD persisted much longer in the blood stream, while fewer amounts were detected in the kidney organ than those of [3H] U-SOD. The elevated renal MPO activity was significantly suppressed by PC-SOD. These results suggest that PC-SOD protected kidney injury in ischemic ARF rats by scavenging O2- on the cell membrane followed by inhibiting neutrophils infiltration.
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