Abstract
Combined pathology is quite common and relevant in dermatology, but at the same time it is insufficiently studied. There is a few available literature data on the multimorbidity of immune-dependent dermatitis. The article presents a clinical case of a patient with diseases united by a common pathogenetic mechanism (vitiligo, lichen planus (LP), autoimmune thyroiditis) and then subjected to a causality transformation with the Gottron’s carcinoid papillomatosis (GCP) development at sites of occurred dermatoses. Papillomatous projections and vegetation characteristic of CGP almost completely replaced the original papular rash characteristic of lichen planus. It changed the clinical picture of the main pathological process, complicated its course, which in turn caused difficulties in timely diagnosis. Clinical and histomorphological examinations of skin biopsies were performed to verify the diagnosis. Histologically, GCP was manifested by epidermal pseudoepitheliomatous hyperplasia at the site lichen planus and vitiligo foci. This clinical case is of interest due to the rare combination of lichen planus with vitiligo in the setting of autoimmune thyroiditis; it confirms the previously expressed assumptions about the possibility of immune-dependent diseases combination. KEYWORDS: multimorbidity, vitiligo, lichen planus, Gottron’s carcinoid papillomatosis, autoimmune thyroiditis, histology, PUVA therapy, cryolysis. FOR CITATION: Tlish M.M., Sycheva N.L., Starostenko V.V. et al. Combined dermatological pathology complicated by Gottron’s carcinoid papillomatosis. Russian Medical Inquiry. 2020;4(10):652–658. DOI: 10.32364/2587-6821-2020-4-10-652-658.
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