Abstract
Background and Objectives: It is believed that angiocentric immunoproliferative lesions are a unique type of extralymphatic lymphoma characterized by localized progressive and destructive lesion in upper aerodigestive tract. We analysis the clinical feature, therapeutic result and prognosis of this disease and then plan further treatment strategy. Materials and Method: The clinical feature, therapeutic modalities and outcomes of 22 patients with angiocentric immunoproliferative lesions were reviewed. Results: The most common symptom is nasal obstruction and B symptom is positive in 8 cases (36%). The lesion frequently invade nasopharynx and oral cavity and regional cervical metastasis is also frequently made. The most common metastatic organ is the lung nevertheless infrequent. The histopathologic grading is either grade 2 (41%) or grade 3 (59%) and the clinical stages by Ann-Arbor classification are almost early stages. Therapeutic modalities were selected among only chemotherapy, only radiotherapy and combined chemotherapy and radiotherapy. Overall 5-year survival rate is 29.6%. No statistical difference of survival rate is found according to both stage and therapeutic modalities. Nevertheless it tends that treatment strategy with only radiotherapy is less effective than the others. Conclusion: The treatment strategy including chemotherapy is suspected to be more effective, especially in advanced or relapsed case. Further studies are needed for establishement of the treatment strategy including chemotherapy. (J Clinical Otolaryngol 2001;12:214-221)
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