Abstract
HIV infection is currently a big problem in medicine and pharmacy. For therapy, antiretroviral drugs are offered, the range of which is constantly increasing. One such drug is atazanavir. When treating, it is very important to create the optimal dosage, which is based on the quantitative content of the substance. For the quantitative determination of the content of atanazavir, the regulatory documentation suggests the method of high-performance liquid chromatography (HPLC). The HPLC method, in addition to its advantages, also has disadvantages in the form of expensive and complex equipment and the need for standard USP samples. In this article, a unified method has been developed that allows to determine the quantitative content of atazanavir in the substance and capsules using the spectrophotometry method using external optical reference samples. Potassium ferricyanide is proposed as an external sample. The optimal conditions for determination are substantiated: solvents - 0.1 M hydrochloric acid solution and ethyl alcohol 95%, analytical wavelength - 302 nm. Conversion factors are determined, calibration graphs are presented. The relative error of determination according to the developed method for the substance was no more than 0.68%, for capsules - no more than 1.32%.
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