Abstract
Introduction. The modern pharmaceutical market offers a very limited range of medicines for the prevention and treatment of chronic venous insufficiency. The original pharmacologically active compound based on the potassium salt of the sulfated derivative of arabinogalactan (Agsular®) is an analog of heparin. Aim. Development of a hydrophilic gel based on Agsular®. Materials and methods. Model compositions were prepared according to traditional methods of gels preparation. The physical and chemical properties of the obtained samples were evaluated by methods of potentiometry, dynamic rheology and dynamic light scattering. The microbiological purity of the gels during storage was also evaluated. Results. The optimal composition of the hydrophilic gel containing Agsular® (1.5%) as the active substance is substantiated. This is a water-aerosil-glycerol-containing composition (the mixture ratio being 1:2:13 respectively). Studies of pH, dynamic viscosity and zeta potential confirm the stability of this gel. The introduction of a preservative (Nipagin 0.1%) ensures the microbiological purity of the gel during storage. Conclusion. The developed hydrophilic gel is a promising mean of prevention and treatment of chronic venous insufficiency.
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