МЕТАБОЛИЧЕСКИЙ ПРОФИЛЬ ПАЦИЕНТОВ С РАКОМ ТОЛСТОЙ КИШКИ

Abstract

With an increase in body mass index, waist circumference, and an increase in blood glucose, the risk of colorectal cancer increases. The aim of the work was to evaluate metabolic predictors of colorectal cancer in patients of the Republic of Khakassia. The case group includes patients with colorectal cancer. The average age of men is 66.5 (62.7-71.4) years, of women - 62.5 (57.2-67.4) years. The «control» group included patients with metabolic syndrome without malignant neoplasms, similar to the «case» group by sex and age: the average age of men - 53.8 (47.3-57.4) years, women - 61.9 (48, 1-61.6) years. The «control» group included patients with metabolic syndrome without malignant neoplasms, similar to the «case» group by sex and age: the average age of men - 53.8 (47.3-57.4) years, women - 61.9 (48, 1-61.6) years. In the case group with colorectal cancer, excess body weight was recorded in 81.3% of patients before the onset of malignant neoplasms, normal and overweight were more common in men, and obesity of the 1st degree - in women. The number of obese and overweight patients increases after the age of 60, regardless of gender. In addition, among patients with colorectal cancer, there is a statistically significant increase in patients with 5-component metabolic syndrome, both among women and among men. By stratifying patients by body mass index, excess body mass was established in all representatives of the «control» group with metabolic syndrome. After 50 years, the number of men with obesity of 1 and 3 degrees increased, and after 60 years - it sharply decreased. The number of women with grade 1 obesity increased sharply by the age of 60, and remained at a later age. The metabolic syndrome among men under the age of 50 is mainly represented by three terms, in the period 50-60 years, the propor- tion of patients with 4 and 5 components increases, and after 60 years, the multicomponent level decreases sharply. Among women, the expansion of components is also associated with an increase in age, however, after 60 years, the number of patients with metabolic syndrome increased sharply.