Abstract
Drugs containing nanoparticles are the subject of considerable interest in the field of pharmacy. They can be excellent diagnostic tools, have therapeutic properties important for the treatment of patients. Nanomaterials in the composition of drugs are widely used as carriers of poorly soluble drugs to increase both bioavailability and delivery. They enhance their therapeutic effect, reduce the harmful side effects associated with toxicity. The growing role of nanocomponent drugs leads to the fact that the quality assessment of such dosage forms should be carried out in accordance with the requirements of the state pharmacopoeia. Compliance with the requirements guarantees the quality and safety of the product. As materials and research methods were used UV spectrophotometer SF-2000, levitation melting using an induction furnace, dosage form components: active substance dioxomethyltetrahydropyrimidine, vaseline, lanolin. Quantitative determination of the components of the developed ointment with nanoparticles, carried out by UV spectrophotometry, showed that the content of the active substance dioxomethyltetrahydropyrimidine in the dosage form corresponded to the standard. The use of the validation process allows us to conclude that this ointment meets the standards and can be used for preclinical studies in order to identify the possibility of its use for the treatment of photodermatitis, ulcers, bedsores.
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