Abstract

Osteoarthritis is a serious joint disease with severe degradation of cartilage tissue, which, according to the World Health Organization, is one of the ten most disabling in developed countries. Due to the poor ability of the articular cartilage to self-regenerate, the treatment of osteoarthritis is a difficult and in many cases unsolvable task, which leads to the need to replace the joint with an endoprosthesis. In this regard, despite the fact that this pathology and its development have been studied in sufficient detail, further fundamental and applied research in this area is still relevant. In recent decades, new technologies have been developed for the regeneration of certain biological tissues, which, under certain conditions, can also be used for the regeneration of cartilage tissue. At the same time, it can be reasonably assumed that the effectiveness of regenerative technologies can be significantly increased using methods (technologies) of regenerative rehabilitation. In this work, we investigate a possible strategy for regenerative rehabilitation of cartilage tissue affected by osteoarthritis by high-frequency loading of the articular surfaces and creating the desired pressure of interstitial fluid in porous cartilage.

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