Abstract
Objective: generalization and analysis of scientific data on the component composition, pharmacological properties and standardization of senna leaves. Materials and methods. The article provides an overview of scientific publications in the journals of the search platforms Scopus and PubMed, as well as the databases of the Russian Science Citation Index. The analysis of the range of herbal medicinal products was carried out according to the data of the State Registers of Medicines of the Republic of Belarus, the Russian Federation and the Republic of Kazakhstan using content analysis, comparison and generalization of data. Results. In addition to the laxative effect, determined by the presence of anthracene derivatives in senna leaves, the complex of their biologically active substances has antimicrobial, hypoglycemic, antioxidant, antifungal and antitumor effects. Also, the chemical composition of the plant is represented by fatty acids, triglycerides, flavonoids, macro- and microelements. The analysis of medicinal herbal preparations based on senna leaves registered in the Russian Federation, the Republic of Belarus and the Republic of Kazakhstan has been carried out. The differences in the methods of their standardization, given in the normative documentation on quality, have been revealed. The scientific experience of using the method of high performance liquid chromatography for the determination of anthracene derivatives in senna leaves is generalized. Conclusion. The complex of biologically active substances of senna leaves exhibits various pharmacological effects, which, possibly, will expand the range of combined preparations based on them. The use of a modern and selective method of high-performance liquid chromatography in the analysis of senna leaves is a very promising direction in the field of standardization of this type of medicinal plant material.
Highlights
The article provides an overview of scientific publications in the journals
The analysis of the range of herbal medicinal products was carried out according to the data of the State Registers
the chemical composition of the plant is represented by fatty acids
Summary
Анализ ассортимента лекарственных растительных препаратов проведен по данным Государственных реестров лекарственных средств Республики Беларусь, Российской Федерации и Республики Казахстан с использованием контент-анализа, сравнения и обобщения данных. Проведен анализ зарегистрированных в Российской Федерации, Республике Беларусь и Республике Казахстан лекарственных растительных препаратов на основе сенны листьев. Обобщен научный опыт использования метода высокоэффективной жидкостной хроматографии для определения антраценпроизводных в сенны листьях. Комплекс биологически активных веществ сенны листьев проявляет различные фармакологические эффекты, что, возможно, позволит расширить спектр комбинированных препаратов на их основе. Применение в анализе сенны листьев современного и селективного метода высокоэффективной жидкостной хроматографии является весьма перспективным направлением в области стандартизации данного вида лекарственного растительного сырья. На фармацевтическом рынке Республики Беларусь число лекарственных растительных препаратов составляет около 11% от всех зарегистрированных лекарственных препаратов, в связи с чем вопросы их разработки и стандартизации остаются весьма актуальными [10]
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