КЛИНИЧЕСКОЕ ЗНАЧЕНИЕ ПОКАЗАТЕЛЯ НЕСПЕЦИФИЧЕСКОЙ И СПЕЦИФИЧЕСКОЙ ЗАЩИТЫ (NLR) В МОЧЕ В КАЧЕСТВЕ ПРОГНОСТИЧЕСКОГО МАРКЕРА ТЕЧЕНИЯ И ИСХОДА РЕЦИДИВИРУЮЩИХ ВОСПАЛИТЕЛЬНЫХ ЗАБОЛЕВАНИЙ МОЧЕВЫХ ПУТЕЙ

Abstract

Аim. The study aims to evaluate the clinical significance of the indicator of nonspecific and specific protection (NLR) in urine as an accessible and objective marker of the type, cause, and possible outcome of recurrent inflammatory diseases of the urinary tract. Materials and Methods. The study included patients with recurrent urinary tract inflammation of various origins. A comparative study of routine laboratory indicators of the ratio of neutrophils and lymphocytes, immune markers of inflammation in urine, and the results of immunohistochemical studies of biopsies of the bladder mucosa was performed. Results. The index of the ratio of cells of nonspecific and specific protection in urine significantly correlates with indicators of phenotyping of T-lymphocytes, the concentration of interleukins in urine, and the composition of cells of the mucous membrane of the bladder with the expression of antigens. Conclusion. The index of the ratio of cells of nonspecific and specific protection (NLR) in urine can be recommended as an additional prognostic marker not only of the type and cause but also of the possible outcome of recurrent inflammatory urological diseases.