Abstract
The aim of the study. To reveal the differences in locomotor activity between the rats of SHR and WKY strains and to estimate expression levels of mRNA of NAP-22 and GAP-43 proteins in the neurons of the parietal cortex and hippocampus. Materials and methods. Locomotor activity of the rats of SHR and WKY strains (4 individuals per strain) was recorded by telemetry during 3 days. Expression levels of mRNA of NAP-22 and GAP-43 proteins in the neurons of the parietal cortex and hippocampus were estimated by real-time PCR in other rats of the strains (10 individuals per strain). The study was conducted on animals from the Biological collection of I.P. Pavlov Institute of Physiology Russian Academy of Sciences. Results. Locomotor activity of SHR rats was high than that of WKY rats although this difference was statistically significant only during the dark phase. Expression levels of mRNA of NAP-22 and GAP-43 proteins in SHR rats was lower than that of WKY rats both in parietal cortex and in hippocampus. Conclusions. High locomotor activity of SHR rats results from hyperactivity of this strain. Thus, these rats can be a good model for the investigations on attention-deficit hyperactivity disorder. Changes in expression levels of mRNA of NAP-22 and GAP-43 can be connected with behavioral disorders.
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