Стан здоров’я новонароджених від матерів із HCV-інфекцією

Abstract

Purpose - to study the health status of newborns from mothers with viral hepatitis С (HCV infection). Materials and methods. A prospective clinical and statistical analysis of the health status of 40 newborns born to mothers with HCV infection (the main group - MG) and 50 newborns born to healthy women (the control group - CG) was performed. The statistical processing of the study results was carried out using standard software Microsoft Excel 5.0 and Statistica 8.0. Results. In children of MG compared to children of CG had a lower Apgar score at birth (p<0.001). An Apgar score ˂7 points in 15.0% (6/40) of newborns of MG (F=4.61; p=0.032) was diagnosed, which was significantly higher than in newborns of CG - 4.0% (2/50), (р<0.001). The frequency of conjugated jaundice in newborns of CG was 4.0% (2/50), while in children of MG it was 17.5% (7/40) (χ2=7.97; p=0.005). Correlation analysis revealed that the Apgar score has medium strength positive correlations with body length (τ=0.266; p<0.001), and the development of conjugated jaundice in newborns has medium negative correlations with these physical parameters at birth as body weight (τ=-0.302; p<0.001) and body length (τ=-0.306; p<0.001), as well as with Apgar score (τ=-0.302; p<0.001) and gestational age at birth (τ=-0.249; p<0.001). Conclusions. The condition of newborns from women with HCV infection is characterized by lower parameters of physical development and a decrease in Apgar score, increased frequency of development of conjugation jaundice. Physical and clinical parameters of newborns from mothers with HCV infection were related to pathological conditions during pregnancy and delivery. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the author.