Abstract
The role of amygdala 5-НТ2А/С receptors in the acquisition, expression, and extinction of conditioned fear as well as in anxiety was studied. Injections of 5-НТ2А/С antagonist (ketanserin, 0.5 µg/0.5 µl) into basolateral amygdala impaired fear expression in the form of freezing and its acquisition, but had no effect on anxiety. Injection of 5-НТ2А/С agonist (DOI, 1 µg/0.5 µl) caused panic-like behavior, increased the locomotor activity but decreased anxiety and fear expression in the form of freezing. Both agonist and antagonist facilitated fear extinction in high-freezing rats. These results suggest that 5-НТ2А/С serotonin receptors in amygdala play an important role in the expression and retention of conditioned fear.
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