Abstract
The collagenase enzyme proteolytic complex used in a gel form will be an alternative to invasive methods and electrophoresis, requiring medical personnel and special equipment. Taking into account the instability of proteolytic enzymes in the aquatic phase, the use of organogel as the collagenase basis makes it possible to create a stable and convenient dosage form for the scar treatment. This study’s aim was the composition of an anti-scar organogel based on Paralithodes camtschatica collagenase development. Aerosil proposed as a thickener. Various technological studies (external signs assessment, distribution on the skin, smearing, pH, proteolytic activity, stability, rheological properties) of gels samples based on lipophilic solvents: dimethicone, cyclomethicone, liquid paraffin, propylene glycol, capril/caprilic triglycerides, were carried out to select the optimal gel-forming agents. The proteolytic activity of the gel with collagenase manifested up to 24 hours, so, it may be used for stabilization. The composition of the components of the dispersion medium, which has acceptable sensory properties for the continuity of treatment, selected. It characterized by thermo- and colloidal stability, acceptable rheological properties. The oleogel on the combination of capril/caprilic triglycerides and dimethicone as a dispersion and aerosil as a thickener was justified, which may be recommended as an anti-scar agent for further research.
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