Abstract
THE AIM of the investigation was to specify the role of components of the renin–ngiotensin-aldosterone system (RAAS) in progressing chronic kidney disease, its renal and cardiovascular injuries. PATIENTS AND METHODS. The concentration of plasma aldosterone (CPA), plasma renin activity (PRA), blood serum creatinine (SCr), creatinine clearance (CCr), total renin plasma (TR), inactive plasma renin (IR) were determined in 214 patients with different forms of chronic glomerulonephritis and different stages of chronic kidney disease (CKD).RESULTS. Increased CPA was noted in the progress of CKD, clear inverse nonlinear dependence between CCr and CPA was established. The linear correlation analysis has revealed highly reliable direct correlation between SCr and CPA and confirmed the inverse correlation between CCr and CPA. No relationships were found between the investigated components of RAAS and levels of arterial pressure, although there were correlations of PRA with TR and of IR with TR. A statistically significant feedback was found between PRA and SCr. CONCLUSION. Aldosterone, A II and rennin can be substantial independent factors of the development and progress of renal and cardiovascular complications in patients with CKD.
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