Полиморфизм генов бета-адренорецепторов и риск эссенциальной гипертензии

Abstract

The aim of the current study was to analyse an association between ADRB1, ADRB2 и ADRB3 gene variants and essential hypertension (EH) in the ethnic group of Tatars residing in the Republic of Bashkortostan (Russian Federation). Design and methods . We performed genotyping of ADRB1 rs1801252, ADRB2 rs1042713 and ADRB3 rs4994 polymorphisms using polymerase-chain reaction with allele-specific primers in the study group consisting of 530 individuals (216 hypertensive patients, 314 controls). Considering the fact that gender is a major risk factor for the development of hypertension before age 45, the study group was composed of male individuals. Results. We detected an association between ADRB2 rs1042713 and EH. ADRB2*A/G genotype was found to be associated with an increased risk of EH (odds ratio, OR = 1,68; p = 0,004); ADRB2*G/G genotype, on the contrary, was shown to be protective against the disease (OR = 0,58; p = 0,01). ADRB2*A/G genotype also marked an increased risk of hypertension in patients with obesity (OR = 3,01; P = 0,01), while ADRB2*G/G genotype carriers with body mass index > 30 kg/m 2 had lower risk of EH (OR = 0,29; P = 0,01) when compared to the control individuals of the same category. Conclusion. Our study has shown that ADRB2 rs1042713 polymorphism is associated with the risk of EH, and the effect is more pronounced in individuals with obesity.