Компартментализация несинаптической пластичности в нейронах на субклеточном уровне

Abstract

One of the most efficient ways of CNS response to the variety of external and internal stimuli is a selective increase of excitability of neurons, acquired, for instance, during learning process. It is now well established, that persistent non-synaptic plasticity that emerging after learning, as well as synaptic one may serve an a substrate for long-term memory. Though, it remains unknown how the non-synaptic plasticity contributes to the alteration of the states of neuronal networks, which the long-term memory depends directly on. The explanation of how the non-synaptic plasticity is translated into the modified states of the neuronal networks and modified behavior remains one of the most important challenges of the contemporary research in the field of learning and memory. Also, little is known about the specific neuronal compartments ofthe axon and dendretic tree of that subjected to plastic changes in the context of morphological features of individual neuron and the efficiency of its input and output synapses subjected to indirect modifications due to non-synaptic plasticity and the influence of non-synaptic plasticity on the efficiency of neuronal synapses.