ВЛИЯНИЕ ИММУНОСТИМУЛИРУЮЩИХ ПРЕПАРАТОВ НА УРОВЕНЬ ИММУННОЙ КОМПЕТЕНЦИИ ТЕЛЯТ

Abstract

The aim of this work was to evaluate the effect of immune stimulating drugs Salus-P-E and Bovistim-K on the quality of colostrum and the immune status of calves after colostrum feeding. The research was carried out on first-calf heifers of the Holstein breed. Three groups of deep-calving cows were selected according to the principle of analogue groups of 10 animals each. Cows of the 1st experimental group were injected intramuscularly in the middle third of the neck Salus-P-E at a dose of 10 ml three times – 60, 30 and 15 days before the expected date of calving; the 2nd experimental group were injected Bovistim-K at the same time and dose; in the control group, biological preparations were not used. Colostrum sampling was carried out twice: within 60 minutes after calving and 24 hours after calving. In the second series of experiments, we studied the clinical and physiological state and blood parameters of newborn calves after feeding colostrum. The colostrum of cows of the 1st and 2nd experimental groups contained more immunoglobulins than control samples by 23.8 and 27.67 g/l; total protein – by 3.08 and 3.32%; the level of caseins – by 0.34 and 0.22%, respectively. Against the background of the immune correction of the organism of deep-calving dams, there is an increase in the amount of hemoglobin, total protein, reserve alkalinity and certain changes in the ratio of protein fractions of blood in newborn calves. In the first day of life, an increase in the blood serum of calves of the 1st and 2nd experimental groups was found compared to the control: albumin by 7.9 and 8.4%; α-globulins – by 18.6 and 15.7%, β-globulins – by 22.1 and 16.9%, γ-globulins – by 24.4 and 21.4%, respectively. Feeding high-quality colostrum (Brix over 24) contributed to an increase in the average daily gains in calves of the 1st and 2nd experimental groups by 18.2 and 20.2%. The use of the immune stimulating drugs Salus-P-E and Bovistim-K increases the immunocompetent properties of colostrum, which contributes to the formation of a high level of colostral immunity in the body of newborn calves, reducing morbidity and improving growth and survival rates.