Морфологічні особливості плаценти при прееклампсії за даними гістохімії

Abstract

One of the important stages in analyzing the causes of complications of pregnancy and childbirth, particularly preeclampsia, is considered to be a natural morphological study of the placenta. The main direction of research is to identify morphological of diagnostic and prognostic criteria of preeclampsia in general, and special lesions of structures of the placenta in particular. The objective: to study the morphological features of the placenta in pregnancy complicated by preeclampsia varying severity according histochemistry and prediction of the potential cardiovascular risks in the future. Patients and methods. Histochemical study of the placenta of women whose pregnancy was complicated by preeclampsia (PE). The first group consisted of placentas from 12 women with mild PE; group II - 9 placentas from women with moderate and severe PE; III group (control) consisted of 15 placentas from women without obstetric and somatic pathology and signs of PE. Comprehensive evaluation of structural features of the placenta included macroscopic examination, organometry and review histology. Results. In the placenta of pregnant women mainly with moderate and severe PE detected in the decidua basalis of individual macrophages with pronounced soudaniennes cytoplasm; thrombosis in the majorsince space, discirculatory disorders in form of ischemic infarcts and compensatory-adaptive reactions according to the type of angiomatosis of individual villis; in the vessels of the placenta and decidual shell identified phenomen of atherosis of the different degree of severity. Conclusion. In women with PE in placenta revealed disorders of lipid metabolism,which may indicate its involvement in the pathogenesis of this disease continue to be one of the prognostic criteria of risk of the development of atherosclerosis and one of the first signals to metabolic disturbances. Key words: preeclampsia, placenta, histochemistry, thrombosis, atherosis, angiomatosis.