Abstract
Ciprofloxacin, as a member of the fluoroquinolone group, is widely used to treat diseases caused by both grampositive and gram-negative bacteria. However, in recent years there has been an increase in resistance to this drug, which may be associated with the overuse of ciprofloxacin due to its broad spectrum of action. In this regard, in order to develop new and effective drugs against drug-resistant pathogens, there is a need to study and analyze such resistance mechanisms to ciprofloxacin as modification of target molecules, changes in drug penetration and plasmid-mediated quinolone resistance. The article presents up-to-date information on genetic mechanisms of bacterial resistance to antimicrobial drugs belonging to the fluoroquinolone group.
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