Abstract
Dalbavancin is a semi-synthetic lipoglycopeptide registered for the treatment of acute bacterial skin and skin structure infections caused by Gram-positive microorganisms, including MRSA. It has a prolonged half-life and excellent tissue levels which allows to its once-weekly administration. Article reviews data of in vitro, in vivo studies and clinical trials results, as well as potential indications of dalbavancin.
Highlights
Dalbavancin is a semi-synthetic lipoglycopeptide registered for the treatment of acute bacterial skin and skin structure infections caused by Gram-positive microorganisms, including methicillin-resistant Staphylococcus aureus (MRSA)
Dalbavancin is a semi-synthetic lipoglycopeptide registered for the treatment of acute bacterial skin and skin structure infections caused by Gram-positive microorganisms, including MRSA
Mendes R.E., Castanheira M., Farrell D.J., et al Update on dalbavancin activity tested against Gram-positive clinical isolates responsible for documented skin and skin-structure infections in US and European hospitals (2011-13)
Summary
Ключевые слова: далбаванцин, MRSA, инфекции кожи и мягких тканей. Далбаванцин – полусинтетический липогликопептидный антибиотик, предназначенный для терапии ИКМТ, вызванных грамположительными возбудителями, в том числе метициллинорезистентными S. aureus. Препарат характеризуется длительным периодом полувыведения и высокой биодоступно стью, что позволяет назначать его 1 раз в неделю, а также низкими показателями МПК и высоким профилем безопасности. В обзоре представлены данные по in vitro, in vivo и клиническим исследо ваниям, а также перспективные показания к применению далбаванцина
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