Abstract
The aim of this work was to study the antitumor, anti-metastatic and metabolic effects of the newly synthesized n, π-chelate complexes Pt2+ with N-allythioureas (complex II and IU complex). The studies used high-metastable strain of transfected Lewis lung carcinoma and HepG2-transformed hepatocyte cells with high activity gamma-glutamate transpeptidases and mouse leukemia cells of L1210 with pronounced aneuploid karyotype and short duplication of population. In the comparative analysis with the classical chemotherapy cisplatin, the II and IV complexes revealed antitumor and anti-metastatic effects and normalization of biochemical disorders, which are confirmed by a decrease in the activity of lactate dehydrogenase and gamma-glutamine transpeptidase, indicating the inhibition of the formation of drug resistance.
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Schedule a callMore From: Bulletin of Taras Shevchenko National University of Kyiv. Series: Problems of Physiological Functions Regulation
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