가토의 체위성 안구운동에 미치는 알코홀의 중추 및 말초효과

Abstract

The role of the central nervous system on generation of positional alcohol nystagmus was evaluated in unanesthetized rabbits with intravenous alcohol injection of 1∼2g/kg, body weight. The body position was changed by rolling, pitching, yawing, and eye movements were measured by means of a standard electronystagmography. Also the effect of intraventricular alcohol injection of 0.2g on eye movement was observed. The results were obtained as follows: By rolling of the whole body, the direction of eye movement corresponded to the direction of horizontal rectus muscles, and fast phase of nystagmus showed the direction of side down position. Also, eye movement appeared when the body position was returned to neutral from unilateral side down position. Vertical eye movements were induced by pitching, which movements of both eyes were in the opposite direction each other. Eye movements induced by yawing were decreased significantly compared with the control group(p<0.0l). Spontaneous nystagmus and head deviation were occurred by unilaterally ventricular injection of alcohol, and those responses were similar to the effect in contralateral side of alcohol injection. These results indicate that the direction of positional alcohol nystagmus in rabbits with monoocular vision is not related to the gravitational direction but consistents to the vestibuloocular reflex. And the central nervous system as well as the vestibular system takes part in the generation of positional alcohol nystagmus.