Abstract
Background: This study has been carried out to investigate the protective effect of Korean Red Ginseng Non-Saponin Fraction (RGNSF) on clinical chemical parameters in male rats acutely exposed to 2,3,7,8-tetrachlorodibenzo-ρ-dioxin (TCDD).<BR>Methods and Results: RGNSF was prepared from red ginseng residues after ethanol extraction of red ginseng. The RGNSF was characterized by the saponin and free sugars of TLC. RGNSF did not contain saponin compounds and consisted of several sugars such as glucose, galactose, and sucrose. To investigate the protective effect of RGNSF on TCDD, forty male rats (Sprague Dawley, 180 ± 20 g) were divided into 4 groups. The normal control group (NC) received the vehicle (i.p.) and saline (p.o.) daily. The only TCDD treated group (TT) received a single dose of TCDD (40 ㎍/㎏, i.p.) and saline. The RGNSF receiving groups were administered p.o. at a daily dose of 100 ㎎/㎏ (RGNSF100) and 200 ㎎/㎏ (RGNSF200) for 3 weeks beginning a week before TCDD exposure. Body-weight gain of TT and RGNSF100 were inhibited after TCDD exposure. The body-weight of RGNSF200 was increased throughout the experimental period, although the increasing rate was slower than that of NC. A decrease in testis weights for the male rats due to TCDD exposure was significantly observed in the RGNSF200 group. Body-weight gain inhibition and the recovery of testis weight by RGNSF administration were dose dependent. Increases in WBC, RBC, hemoglobin, and hematocrit by TCDD intoxication were attenuated by RGNSF administration but were not significant. Increasing AST toxicity by TCDD was significantly inhibited by RGNSF administration with a dose-dependent manner.<BR>Conclusions: These results suggest that RGNSF might be a useful protective agent against TCDD, an endocrine disruptor.
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