Фармакологические эффекты ремаксола при механической желтухе неопухолевого происхождения

Abstract

A study of 35 patients, whom operated by obstructive jaundice of neoplastic origin was done. They were divided into 2 groups: І (comparison groups, n = 15) - in the early postoperative period patients were given standard therapy and II (studied groups, n = 20) - Remaxol was included in the scheme of traditional treatment. In the study dynamics were carried out laboratory and biochemical tests: malonic dialdehyde (MDA) and diene conjugates (DC); phosphalipase A2 (PL A2); hypoxia ratio (HR); middleweight molecules (MWM), total (TAC) and effective albumin concentration (EAC), toxicity index (TI), total bilirubin (TB), alanine aminotransferase (ALT), activated partial thromboplastin time (APTT) and fibrinogen. Thromboelastography (USA) was used to assess the state of the hemostasis system. It was established that postoperative patients in the early time had oxidative stress, increased phospholipase activity, endotoxicosis syndrome, hemostatic disorders (hypercoagulation and hypofibrinolysis), which persisted throughout the observation period. The inclusion Remaxol in traditional therapy led to suppression of the intensity of lipid peroxidation (LP), reduction of phospholipase activity, relief of endogenous intoxication and hypoxia, restoration of blood coagulation-lytic status. The most significant effect of the drug was determined in the first 3 days after surgery.