Abstract
Ectoparasites are a serious problem for veterinarians and pet owners.
 Insectoacaricidal preparation BARS®, developed by NVC Agrovetzashchita LLC, is a multicomponent insectoacaricide and is produced in the form of drops at the withers. For cats as active substances in 1 ml contains: fipronil ‒ 100 mg, cyfluthrin ‒ 2.5 mg, piperonyl butoxide ‒ 0.5 mg, diflubenzuron ‒ 1 mg.
 Purpose of the study. To study the tolerability of the drug during its repeated use in cats at a therapeutic dose of 0.5 ml/5 kg and a double therapeutic dose of 1 ml/5 kg of body weight with daily skin application for 7 days.
 
 Materials and methods. To study the tolerability of the Insectoacaricidal preparation BARS®, 3 groups of cats were formed, 10 animals each (2 experimental and 1 control).
 Results. During the experiment, there were no external signs of intoxication in cats. All animals of the experimental groups were active. The reaction to external stimuli is preserved. The body temperature of the animals throughout the experiment remained within the physiological range in all groups.
 Conclusion. The drug in recommended doses is well tolerated by cats, does not adversely affect the general physiological state, morphological and biochemical parameters of blood, and physical and chemical parameters of urine. Also, they do not have a skin-resorptive and locally irritating effect.
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