Abstract
Enterosorbents based on lignin hydrolised are able to adsorb in the intestine different kinds of toxins, drugs, salts of heavy metals etc. Nowadays, such drugs are widely applied during the treatment of the adults and children from the first year of life due to its safety and proven efficacy. Objective. To study the morphology and the adsorption centers on the surface of the enterosorbent "Filtrum-STI" based on lignin hydrolised. To develop a methodology for determination the adsorption activity of the drug "Filtrum-STI" and to measure qualitatively and quantitatively its adsorption activity to low molecular weight toxins and heavy metals. Materials and methods. The morphology of the sample’s surface was investigated on an Olympus BX-51 optical microscope. IR spectra were obtained using a Thermo Nicolet Nexus 470 FT-IR infrared Fourier spectrometer. Visual identification of the adsorption activity of the enterosorbent was carried out using methylene blue and methyl orange, recommended by the RF SPh as models of low molecular weight toxins. The methodology of determination the adsorption activity to heavy metal cations was developed and the measurements of this activity were carried out using reverse complexometric titration towards Pb2+ cation. Results. Micrographs of the sample "Filtrum-STI" demonstrate the heterogeneity of its surface morphology, the tablet consists of small particles. IR spectroscopy confirmed the presence of active adsorption centers on the surface of lignin hydrolysed. Adsorption of low molecular weight toxins from aqueous solutions was obviously revealed after 15 minutes for all toxins. It is estimated that the adsorption activity of the drug is preserved at physiological pH. The mass content of adsorbed Pb2+ cations was determined by the method of reverse complexometric titration, was demonstrated that w = 19.44 ± 0.92% of cations were adsorbed. Conclusion. A methodology of the determination the adsorption activity of the enterosorbent "Filtrum-STI" was developed and successfully tested, it allowed to confirm the high adsorption properties of the studied drug to a wide range of markers in various media. Key words: enterosorbent, lignin hydrolysed, "Filtrum-STI", adsorption activity, toxins, adsorption centers
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