СОВРЕМЕННЫЙ ВЗГЛЯД НА ГЕНЕТИЧЕСКИЕ АСПЕКТЫ РАЗВИТИЯ ЯЗВЕННОЙ БОЛЕЗНИ

Abstract

Introduction. Despite a considerable quantity of studies focused on the etiology and pathogenesis of ulcer disease, this condition continues to be one of the most relevant in the modern gastroenterology due to its prevalence, relapse rates, and the development of ulcerative-destructive complications. This article deals with the influence level of the genetic predisposition to forming gastric and duodenal ulcers, including from the standpoint of the interrelation between the candidate gene and the disease pattern, considering various ethnic groups. Aim. Based on the analysis of scientific medical literature, we are aiming at describing the current data on the molecular genetic basis of gastric and duodenal ulcers, given its wide prevalence among the population and its great medical and social significance. Materials and Methods. We analyzed publications in databases, such as eLibrary, Scopus, and Pubmed, as well as in science search engines, such as Google Scolar and Web of Science. Over 150 sources were studied in total, of which the most significant ones are included in our references herein. Results and Discussion. The article reflects a contemporary view of the epidemiological and etiopathogenetic aspects of developing gastric and duodenal ulcers with a focus on the role of polymorphism of candidate genes in forming such pathology. Conclusion. The analysis of this literature review showed the importance of how genetic factors affect the risk of developing gastric and duodenal ulcers, as well as the relevance of further studies thereof followed by potentially developing some programs aimed at the primary prevention of ulcer disease and a personalized approach to health care delivery.