Abstract
Cryoablation is a method of choice in treatment of solid tumors of dii¬€erent localization. In addition to the destruction of pathological tissue, the cryoablation causes to complex changes in the immune system. This paper briei¬‚y discusses the implementation of the abscopic ei¬€ect after cryosurgery of tumors, as well as possible changes in the immune system that accompany it. The abscopic ei¬€ect is achieved with a release of antigens from the destroyed cells, which trigger a cascade of immune reactions. This article summarizes the results of the combined use of cryoablation and immunotherapeutic methods, in particular adoptive therapy. The introduction of dendritic cells in combination with cryoablation can signii¬cantly enhance antitumor immunity and reduces the risk of relapse. Probl Cryobiol Cryomed 2019; 29(4): 297-302
Highlights
Cryoablation is a method of choice in treatment of solid tumors of different localization
The main tasks of cryoablation are the destruction of tumor tissue, inactivation of tumor-inducing cancer stem cells (CSCs) and the blocking of their migration from the primary tumor focus [1]
Later studies in a model of glioma in mice showed that after cryoablation of the tumor, an antitumor cellular immune response was induced in the form of an increase in the number of CD3+ and CD4+ T cells, as well as natural killer (NK) cells in blood [27]
Summary
Cryoablation is a method of choice in treatment of solid tumors of different localization. The antitumor effect of cryoablation is focused to the cells of the primary tumor. [21] через 4 недели после криоаблации в опухоли предстательной железы пациента отмечали снижение количества Т-регуляторных клеток, проявляющих иммуносупрессорные свойства, причем этот эффект пролонгировался вплоть до 8-й недели.
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