Abstract
The paper considers the synthesis and analysis of the reported data on the use of the parameters of spectral analysis when studying the heart rate variability (HRV) in rats. There were demonstrated the criteria for electrocardiographic equipment to perform studies in small mammals, substantiated the indices of duration of electrocardiogram (ECG) recording and indicated the necessity in stationary state of animals during ECG recording. When describing the ranges of spectral frequencies and data-based reports we suggested the parameters of HRV spectral analysis during 5-minute ECG recording in conscious rats such as: TP – 0.015–3 Hz; VLF – 0.015–0.04 Hz; LF – 0.05–0.79 Hz; HF – 0.8–3 Hz. The paper pointed to the need of performing extra-studies on the Mayer wave frequency, as well as the expediency of HRV spectral analysis together with respiration diagram recording. To clarify the parameters of spectral frequencies we recommended the findings comparing with the results of other research methods of HRV. The data of statistical processing of cardiointervalograms during ECG recording in unrestrained rats will enable to specify the selected parameters, accept a common protocol of HRV spectral analysis in this animal species and evaluate their vegetative status. Probl Cryobiol Cryomed 2015; 25(3):235-245.
Highlights
Состояние организма в целом и его равновесие с внешней средой во многом определяется качеством функционирования сердечно-сосудистой системы [1,2,3,4,5, 25, 30, 60]
Центральная нервная система контролирует уровни активности симпатического и парасимпатического отделов по механизму обратной связи [4, 5, 23, 53, 56]
For the most heart rate variability (HRV) indices in human there were revealed such high correlations as: the RR-interval value was positively and high correlating with the mean of standard deviations for all 5-min sites (SDNN-i), Very low frequency (VLF), LF, HF, and negatively with the Baevsky index and mode amplitude (AMo) [7, 21, 30]
Summary
Состояние организма в целом и его равновесие с внешней средой во многом определяется качеством функционирования сердечно-сосудистой системы [1,2,3,4,5, 25, 30, 60]. In this paper we have attempted to present and summarise the reported data on the use of parameters of HRV spectral analysis in rats, as well as to determine the most optimal frequency ranges.
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