Abstract
Currently, thyroid diseases are one of the key problems of modern endocrinology, where the restoration of the thyroid parenchyma after exposure to negative factors and the direction of proliferative processes remain relevant. We conducted a study of the material obtained from deceased individuals as part of a standard pathoanatomical study, followed by animmunohistochemical staining of the expression of nonspecific markers of proliferative activity.It was found that the proliferative activity of thyrocytes increases from the upper to the lower part of the thyroid lobe. Also, in a comparative analysis of the central and peripheral zones, it was found that in normal conditions, the source of neoplasm of thyrocytes is located in the central zone, while when the tissue is involved in the pathological process, an increase in the expression of Ki-67 and PHH3 occursin the peripheral zone.The mitotic activity of cells can lead to the development of thyropathy and disruption of thyroid homeostasis,which serves as the basis for screening the thyroid gland in patients with chronic endogenous intoxication syndrome.
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