Abstract
At the Federal Scientific and Clinical Center of the Federal Medical and Biological Agency of Russia, an analysis of 62 patients with cancer pathology and other pathologies complicated by hydrothorax was performed. Method: methylation of SHOX2, DAPK1, RAR-beta and miR-375 genes using methyl-sensitive PCR. The development of the oncological process is accompanied by genetic polymorphism of genes, including SHOX2, DAPK1, RAR-beta and miR-375. The possibility of predicting oncological pathology and facilitating the search for the primary source of the oncological process in patients with pleural effusion of unknown origin through the study of the studied genes was revealed. Using the MedCalc version 12.3.0.0 program, 3 reliable systems of cancer markers were obtained for methylation of genes of a group of genes: the first is SHOX2, miR-375 (sensitivity — 62.0%, specificity — 82.0%), the second is SHOX2 + miR-375 + DAPK1 (65.0 and 76.0%, respectively), the third is SHOX2 + RAR-beta + miR-375 + DAPK1 (36.0 and 94.0%, respectively). It is advisable to conduct a genetic study of pleural fluids in patients with hydrothorax of unknown etiology.
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Schedule a callMore From: Medical Bulletin of the Main Military Clinical Hospital named after N.N. Burdenko
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