Abstract
The aim of this study was to evaluate the effects of exercise detraining on bone mineral density (BMD), bone metabolism marker and OPG, RANKL mRNA expression of bone marrow cell in ovariectomized rats. Female Sprague-Dawley rats were divided into OVX (ovariectomy, n=10), OVX-EXE (ovariectomy-combined exercise, n=10), and OVX-EC (exercise cessation after combined exercise, n=10). Combined exercise training was performed on a treadmill and ladder adapted to rats in alternate days (4 days/wk, for 12 wk). This was followed by 8 week of exercise detraining. Compared to the OVX group, exercise intervention increased BMD and bone breaking force (p<0.05). It is also serum bone metabolic-related factors (CTx-1, IL-1β, IL-6) and OPG mRNA were significant difference (p<0.05). After the exercise detraining period, all variable in the OVX-EXE groups were still greater than in the OVX groups. These results suggest that regular exercise is an effective therapeutic strategy to prevent and delay postmenopausal osteoporosis and its effectiveness is still preserved after exercise detraining.
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